Drug discovery and development – Page 10
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NewsChemistry Nobel predictions range from free-radical chemistry to MOFs
Data-crunching goes up against gut feeling as the chemistry community weighs in on their favourites for the world’s top chemistry prize
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ResearchProgrammable peptoid template for disrupting protein–protein interactions inside cells
System optimises residues involved in binding target independently from those that promote membrane permeability
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ResearchMethod to make unusual oligonucleotides could be a boon for gene therapy drugs
Synthesis can insert unusual linkages into DNA molecules while rivalling industry standard chemistry in speed and efficiency
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BusinessFully synthetic proteins make tailored medicines
Bright Peak Therapeutics makes modified protein drugs from scratch
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NewsExplainer: The science of alkyl nitrites aka poppers
From their origins as 19th century angina treatment to becoming an important part of gay subculture, these recreational drugs exist in a legal limbo
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BusinessUS grants Pfizer’s Covid-19 vaccine full approval
WHO calls for delay to booster programmes to allow more global distribution
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WebinarAutomated capsule chemistry with Synple: do more, faster
Synple’s automated synthesis technology allows discovery chemists to accelerate research and improve efficiency
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BusinessThe multi-pronged search for Covid-19 treatments
Drugs that block infection or reduce inflammation will complement vaccine protection
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BusinessBudget cuts at UK medicines regulator raise eyebrows
MHRA to cut 300 jobs amid financial pressures arising from Brexit
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BusinessBrewing up plant-inspired medicines
Antheia reconstructs complex biochemical pathways in yeasts to speed up production of natural product-based drugs
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BusinessDeveloping countries sidelined in Covid-19 vaccine scramble
Lack of funds and local manufacturing capacity has prevented Covax from competing with wealthier nations’ self-interest
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ArticlePeptones: over 100 years of life-saving innovation
After a century, peptones continue to play a vital role in biopharmaceutical innovation
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BusinessPfizer backs protein degrader drugs with Arvinas deal
$1bn investment to commercialise breast cancer treatment
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WebinarHarness the power of electricity to make organic compounds
Join us to learn how to use batch-type cells in preparatory electrosynthesis
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FeatureOne hundred years of insulin
Mike Sutton looks at the journey the diabetes treatment took from the Toronto miracle to mass-production – via a controversial trip to Stockholm
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OpinionOpening up a cellular black box
Working out how biomolecular condensates work may reveal a lot about the success or failure of different drugs
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NewsRace to understand Sars-CoV-2 variants amid fears virus might evade vaccines
Biochemical basis behind coronavirus variants’ success could hold key to defeating them
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BusinessBMS and Eisai agree antibody-drug conjugate commercialisation deal
Companies will jointly develop cancer treatment, with BMS paying up to $3 billion for shared rights
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FeatureSupermetals versus superbugs
With pathogenic bacteria rapidly overcoming our arsenal of organic antibiotics, James Mitchell Crow asks if it is time to revisit metal-based antimicrobials
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BusinessRegeneron’s Covid-19 antibodies help those who can’t make their own
Regn-Cov2 reduces deaths and shortens hospitalisation for these patients, even when given at late stages of infection