Drug formulation and delivery – Page 6
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ResearchResponsive nanoparticles target sight-stealing fungus
Eye drop tricks fungal eye infection into self-destruction
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FeatureDelivering gene therapy
After some well-publicised problems, gene therapy – delivering DNA into people’s cells using viruses – is booming, Anthony King finds
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ResearchBlue nanoparticles mop up radioactive element
Nanosized Prussian blue formulation removes radioactive caesium from body faster than commercial treatment
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FeatureIntracellular delivery
Drugs that can enter cells and take useful payloads with them are maturing, finds Andy Extance
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FeaturePersonalised skincare
Nina Notman explores some of the latest scientific approaches skincare companies are using in the quest to develop high-earning anti-ageing cosmetics
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ResearchDNA suitcases packed with gene therapy cargo
Nano-sized capsules can be unlocked to release drugs on demand
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ResearchConnectosomes smuggle drugs across membranes
Engineered vesicles could cut drug side-effects by delivering them straight into cells using cellular ‘airlocks’
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ResearchFreeze-dried cell parts for hassle-free molecule manufacturing
‘Just add water’ reaction pellets allow drugs and vaccines to be produced without special equipment or training
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OpinionHow to solve global health inequality
Our skills as scientists hold the answer, says the Bill & Melinda Gates Foundation
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ResearchMagnetic fields deliver cancer-killing bacteria to tumour’s heart
Guided microbes packed with drugs can reach the parts of cancers that other drugs just can’t reach
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ResearchKamikaze bacteria travel deep inside tumours to deliver deadly cargo
Engineered bacteria in tandem with chemotherapy show promise in mouse model of cancer
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ResearchMiniature carbon bottles hold promise as nano-reactors
Nanobubbles with hydrophobic interiors also have potential as drug delivery agents
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ResearchMicroscopic cannon battery to blast disease
Cannon-like tubes shoot tiny bullets when triggered by ultrasound and could deliver drugs
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ResearchOral delivery of anticancer drug
Researchers endeavour to limit drug side effects and injections for cancer patients
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ResearchCobalt could cut costs for pharma ingredients
Carboxylic acids and esters hydrogenated without the need for expensive precious metals
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FeatureA new hope in HIV prevention
New microbicide products could turn the tide against Aids for women in Africa, reports Dinsa Sachan
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FeatureOligonucleotide drugs step up
Structural innovations are overcoming oligonucleotide drugs’ historical flaws, discovers Andy Extance
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BusinessPorous pills could be largest industrial 3D printing use
US grants first-of-a-kind approval for Aprecia’s epilepsy tablets exploiting porous structure
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ResearchSingle polymer pill could deliver entire drug course in one go
Flexible elastomer ring springs open to stay in stomach and could slowly release drugs over days
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OpinionMissing the target
There are plenty of things that small molecule drugs can’t touch, says Derek Lowe, and it’s not for want of trying